Propafenone added to ibutilide increases conversion rates of persistent atrial fibrillation

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Propafenone added to ibutilide increases conversion rates of persistent atrial fibrillation.

OBJECTIVE To assess the effectiveness and safety of pharmacological conversion of persistent atrial fibrillation (AF) with a combined propafenone plus ibutilide regimen. METHODS AND RESULTS 100 consecutive patients (66 men, mean (SD) age 65 (10) years) with persistent AF (mean (SD) duration 99 (92) days) admitted for elective pharmacological cardioversion were randomly assigned to treatment w...

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Ibutilide added to propafenone for the conversion of atrial fibrillation and atrial flutter.

OBJECTIVES We evaluated the safety and efficacy of ibutilide when added to propafenone in treating both paroxysmal and chronic atrial fibrillation (AF) and atrial flutter (AFL). BACKGROUND The effects of ibutilide in patients with paroxysmal or chronic AF/AFL who were pre-treated with propafenone have not been previously evaluated. METHODS Oral propafenone was initially given in 202 patient...

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Conversion of Persistent Atrial Fibrillation After Radiofrequency Ablation by Ibutilide.

Ablation of peristent AF remains challenging with questions unanswered about what the ideal next step after pulmonary venous isolation should be. Ibutilide is a highly effective class III agent for cardioversion of acute-onset atrial flutter and fibrillation, with limited clinical use due to risks of ventricular pro-arrhythmias. However, results from the on-going MAGIC-AF trial may re-invigorat...

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Role of Ibutilide in Atrial Fibrillation.

Ibutilide is primarily used for the acute termination of atrial f ib r i l l a t ion and a t r ia l f lu t te r especial ly of recent onset . I ts efficacy for ventricular arrhythmias is unknown and is not approved for their treatment. Also, since it can’t be used orally, it has no role in long-term prevention of recurrence of atrial arrhythmias. The ECG effects of the drug are the same as seen...

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Amiodarone versus propafenone for conversion of chronic atrial fibrillation: results of a randomized, controlled study.

OBJECTIVES The purpose of this study was to investigate the efficacy and safety of amiodarone and propafenone in the conversion of chronic atrial fibrillation in a prospective, randomized, placebo-controlled study. BACKGROUND The effectiveness of amiodarone and propafenone in the treatment of patients with chronic atrial fibrillation has not been adequately studied. METHODS One hundred one ...

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ژورنال

عنوان ژورنال: Heart

سال: 2006

ISSN: 1355-6037

DOI: 10.1136/hrt.2005.072322